DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

Heliospheric and Interstellar Phenomena Deduced From Pickup ion Observations

Pickup ions, created by ionization of slow moving atoms and molecules well inside the heliosphere, provide us with a new tool to probe remote regions in and beyond the heliosphere and to study injection and acceleration processes in the solar wind. Comprehensive and continuous measurements of H, He, C, N, O, Ne and other pickup ions, especially with the Solar Wind Ion Composition Spectrometer (SWICS) on both Ulysses and ACE, have given us a wealth of data that have been used to infer chemical and physical properties of the local interstellar cloud. With SWICS on Ulysses we discovered a new population of pickup ions, produced from atomic and molecular sources deep inside the heliosphere. The velocity distributions and composition of these “inner source” pickup ions are distinctly different from those of interstellar pickup ions, showing effects of strong adiabatic cooling, and a composition resembling that of the solar wind. Strong cooling indicates that the source of these pickup ions lies close to the Sun. The similarity of composition of inner source heavy ions to that of the solar wind implies that the dominant production mechanism for these pickup ions involves the absorption and re-emission of solar wind from interplanetary dust grains. While interstellar pickup ions are the seed population of the main Anomalous Cosmic Rays (ACRs), inner source pickup ions may be an important source of the rarer ACRs such as C, Mg, Si, S, and Fe. We present new results and review previous work with an emphasis on characteristics of the local interstellar cloud and properties of the inner source. This revised version was published online in August 2006 with corrections to the Cover Date.     

Developing countries and remote sensing: how intergovernmental factors impede progress

Developing countries lag significantly behind more advanced nations in the local adoption and application of satellite remote sensing technology. Narrowing this gap through appropriate international cooperation is, however, often constrained by national interests and priorities. The paper presents an overview of several of these inter-governmental constraints using as its main basis the outcomes of recent regional and international conferences hosted by the United Nations. Future enhancement of international cooperation in remote sensing will occur best within settings where both developing and technologically advanced countries are sensitive and responsive to each other's concerns.     

The applications of lower power satellites for direct television broadcasting

The use of 12 GHz satellites for TV broadcasting directly to individual homes and small communities has been the subject of analysis and design study by groups in many countries. Implementation of the concept has been slow to follow because of the high satellite transmitter powers of from 100 to 450 W that have usually been determined to be necessary. Accumulated experience in Canada with 12 GHz operation and the evolution of technology are leading to changes in the concept of direct broadcasting such that lower power satellites may be capable of meeting the requirements.

Hermes, the Canadian/U.S. 12/14 GHz Communications Technology Satellite, has been in use for over 3 years in a program of experiments and measurements. This program has included an extensive six month experiment in direct broadcasting to 7 small communities. Experience with Hermes has shown that the signal strength is stable over long periods of time and that in Canada, significant precipitation attenuation at 12 GHz is of relatively short duration and typically occurs only during certain seasons. Operation with low propagation margins is feasible if some picture degradation and some outages at these times are acceptable. The frequency and duration of occurrence of outages can be controlled by the Earth station G/T which is cost sensitive. An individual may choose to use a low cost system with a small antenna and accept a degraded picture and outages at some times. A small community may choose to pay more for a larger antenna and lower noise receiver to achieve better performance.

Developments in technology are reducing the noise figure of mass-producible receivers from more than 6 dB to as low as 4 dB. Another technology contribution is the use of reduced bandwidth and other signal processing techniques in low-cost receivers. While use of such techniques may introduce distortions that would be unacceptable in rebroadcasting systems, there is little impact for individual and community reception. Use of both technologies reduce the required satellite EIRP or ground terminal G/T.

A field trial was begun in April 1979 to test these concepts for use in television program delivery. One hundred Earth stations capable of being tuned across a 500 MHz band and having antennas with diameters of either 1.2 m or 1.8 m are being installed for a test in Canada to receive TV signals from the 20 W transponders of ANIK-B (peak EIRP of 51 dBw) on an experimental basis. The acceptability of the video signals and the technical performance of the low-cost terminals in the bands of non-technical users are being evaluated.

The paper will summarize the concept of TV broadcasting with lower power satellites and describe the results to date of the ANIK-B field trials.     

Magnetosphere Imaging Instrument (MIMI) on the Cassini Mission to Saturn/Titan

The magnetospheric imaging instrument (MIMI) is a neutral and charged particle detection system on the Cassini orbiter spacecraft designed to perform both global imaging and in-situ measurements to study the overall configuration and dynamics of Saturn’s magnetosphere and its interactions with the solar wind, Saturn’s atmosphere, Titan, and the icy satellites. The processes responsible for Saturn’s aurora will be investigated; a search will be performed for substorms at Saturn; and the origins of magnetospheric hot plasmas will be determined. Further, the Jovian magnetosphere and Io torus will be imaged during Jupiter flyby. The investigative approach is twofold. (1) Perform remote sensing of the magnetospheric energetic (E > 7 keV) ion plasmas by detecting and imaging charge-exchange neutrals, created when magnetospheric ions capture electrons from ambient neutral gas. Such escaping neutrals were detected by the Voyager l spacecraft outside Saturn’s magnetosphere and can be used like photons to form images of the emitting regions, as has been demonstrated at Earth. (2) Determine through in-situ measurements the 3-D particle distribution functions including ion composition and charge states (E > 3 keV/e). The combination of in-situ measurements with global images, together with analysis and interpretation techniques that include direct “forward modeling’’ and deconvolution by tomography, is expected to yield a global assessment of magnetospheric structure and dynamics, including (a) magnetospheric ring currents and hot plasma populations, (b) magnetic field distortions, (c) electric field configuration, (d) particle injection boundaries associated with magnetic storms and substorms, and (e) the connection of the magnetosphere to ionospheric altitudes. Titan and its torus will stand out in energetic neutral images throughout the Cassini orbit, and thus serve as a continuous remote probe of ion flux variations near 20R _S (e.g., magnetopause crossings and substorm plasma injections). The Titan exosphere and its cometary interaction with magnetospheric plasmas will be imaged in detail on each flyby. The three principal sensors of MIMI consists of an ion and neutral camera (INCA), a charge–energy–mass-spectrometer (CHEMS) essentially identical to our instrument flown on the ISTP/Geotail spacecraft, and the low energy magnetospheric measurements system (LEMMS), an advanced design of one of our sensors flown on the Galileo spacecraft. The INCA head is a large geometry factor (G ∼ 2.4 cm² sr) foil time-of-flight (TOF) camera that separately registers the incident direction of either energetic neutral atoms (ENA) or ion species (≥5^∘ full width half maximum) over the range 7 keV/nuc < E < 3 MeV/nuc. CHEMS uses electrostatic deflection, TOF, and energy measurement to determine ion energy, charge state, mass, and 3-D anisotropy in the range 3 ≤ E ≤ 220 keV/e with good (∼0.05 cm² sr) sensitivity. LEMMS is a two-ended telescope that measures ions in the range 0.03 ≤ E ≤ 18 MeV and electrons 0.015 ≤ E≤ 0.884 MeV in the forward direction (G ∼ 0.02 cm² sr), while high energy electrons (0.1–5 MeV) and ions (1.6–160 MeV) are measured from the back direction (G ∼ 0.4 cm² sr). The latter are relevant to inner magnetosphere studies of diffusion processes and satellite microsignatures as well as cosmic ray albedo neutron decay (CRAND). Our analyses of Voyager energetic neutral particle and Lyman-α measurements show that INCA will provide statistically significant global magnetospheric images from a distance of ∼60 R _S every 2–3 h (every ∼10 min from ∼20 R _S). Moreover, during Titan flybys, INCA will provide images of the interaction of the Titan exosphere with the Saturn magnetosphere every 1.5 min. Time resolution for charged particle measurements can be < 0.1 s, which is more than adequate for microsignature studies. Data obtained during Venus-2 flyby and Earth swingby in June and August 1999, respectively, and Jupiter flyby in December 2000 to January 2001 show that the instrument is performing well, has made important and heretofore unobtainable measurements in interplanetary space at Jupiter, and will likely obtain high-quality data throughout each orbit of the Cassini mission at Saturn. Sample data from each of the three sensors during the August 18 Earth swingby are shown, including the first ENA image of part of the ring current obtained by an instrument specifically designed for this purpose. Similarily, measurements in cis-Jovian space include the first detailed charge state determination of Iogenic ions and several ENA images of that planet’s magnetosphere.This revised version was published online in July 2005 with a corrected cover date.     

Initial observations of low energy charged particles near the Earth's bow shock on ISEE-1

We report initial measurements from the ULECA sensor of the Max-Planck-Institut/University of Maryland experiment on ISEE-1. ULECA is an electrostatic deflection — total energy sensor consisting of a collimator, deflection analyzer and an array of solid state detectors. The position of a given detector, which determines the energy per charge of an incident particle, together with the measured energy determine the particle's charge state. We find that a rich variety of phenomena are operative in the transthermal energy regime (10 keV/Q to 100 keV/Q) covered by ULECA. Specifically, we present observations of locally accelerated protons, alpha particles, and heavier ions in the magnetosheath and upstream of the Earth's bow shock. Preliminary analysis indicates that the behavior of these locally accelerated particles is most similar at the same energy per charge.     

Ionization processes in the heliosphere — Rates and methods of their determination

The rates of the most important ionization processes acting in interplanetary space on interstellar H, He, C, O, Ne and Ar atoms are critically reviewed in the paper. Their long-term modulations in the period 1974 – 1994 are reexamined using updated information on relevant cross-sections as well as direct or indirect data on variations of the solar wind/solar EUV fluxes based on IMP 8 measurements and monitoring of the solar 10.7 cm radio emission. It is shown that solar cycle related variations are pronounced (factor of 3 between maximum and minimum) especially for species such as He, Ne, C for which photoionization is the dominant loss process. Species sensitive primarily to the charge-exchange (as H) show only moderate fluctuations 20% around average. It is also demonstrated that new techniques that make use of simultaneous observations of neutral He atoms on direct and indirect orbits, or simultaneous measurements of He⁺ and He⁺⁺ pickup ions and solar wind particles can be useful tools for narrowing the uncertainties of the He photoionization rate caused by insufficient knowledge of the solar EUV flux and its variations.     

Solar wind helium isotopic composition from SWICS/ULYSSES

This is the first study of the isotopic composition of solar wind helium with the SWICS time-of flight mass spectrometer. Although the design of SWICS is not optimized to measure³He abundances precisely,⁴He/³He flux ratios can be deduced from the data. The long term ratio is 2290±200, which agrees with the results obtained with the ICI magnetic mass spectrometer on ISEE-3 and with the Apollo SWC foil experiments.The ULYSSES spacecraft follows a trajectory which is ideal for the study of different solar wind types. During one year, from mid-1992 to mid-1993, it was in a range of heliographic latitudes where a recurrent fast stream from the southern polar coronal hole was observed every solar rotation. Solar wind bulk velocities ranged from 350 km/s to 950 km/s which would, in principle allow us to identify velocity-correlated compositional variations. Our investigation of solar wind helium, however, shows an isotopic ratio which does not depend on the solar wind speed.     

Atomic and molecular hydrogen in interstellar space

This paper reviews the present state of knowledge of the abundances and physical state of interstellar atomic and molecular hydrogen. Much new data in this area have been obtained in recent rocket observations. There have also been new developments as a result of ground-based infrared and 21-cm observations, and theoretical research.Rocket observations of the Lyman- interstellar absorption line of atomic hydrogen indicate that, in many directions in the sky, atomic hydrogen is up to a factor of 10 less abundant than previously indicated by 21-cm emission measurements. In the direction of the Orion Nebula, most of the absorbing gas appears to be concentrated in the near vicinity of the nebula and to have a temperature considerably lower than the average of 100 K obtained from 21-cm emission measurements. Molecular hydrogen appears essentially absent from the general interstellar medium, as confirmed by theoretical studies of photodissociation processes. However, ground-based infrared and 21-cm studies indicate that the hydrogen in dark dust clouds is mostly molecular.     

工件表面轮廓均方根斜率的光散射测量

描述并确定具有明显纹理粗糙表面均方根斜率的光散射技术(均方根斜率是联合表面轮廓高度和波长特性的混合参数)。称为散射光锥法(The scattered light-conemethod)的该技术是基于激光角散射检测阵列(DALLAS——Defector Array for Laser LishtAngular Scattering),它用于测量粗糙表面散射光角分布的仪器。均方根斜率是从DALLAS光散射图象的角宽得到的。一般可以发现角宽(即估计的均方根斜率)对光的入射角和散射角变化相当大时是不敏感的。这些结果与表面材料无关,并且对正弦和随机粗糙表面都是有效的。介绍了散射光锥法的测量原理、实验、数据分析和几点结论。